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. 1974 Aug 31;3(5930):545-8.
doi: 10.1136/bmj.3.5930.545.

Methyldopa liver damage

P J Toghill, P G Smith, P Benton, R C Brown, H L Matthews

Methyldopa liver damage

P J Toghill et al. Br Med J. .

Abstract

Twenty patients are described in whom liver damage appeared to be directly related to the administration of methyldopa. Sixteen had hepatitic syndromes from which they recovered on stopping methyldopa; four of these patients had recurrences of jaundice after a second course of the drug. Features suggestive of active chronic hepatitis were found in two patients. There were two deaths attributed to methyldopa, one of these being in a patient with pre-existing undiagnosed macronodular cirrhosis.

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