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. 1974;15(3):381-97.
doi: 10.1186/BF03547466.

Some acute metabolic effects of parathyroid hormone in sheep

J Persson, J Luthman

Some acute metabolic effects of parathyroid hormone in sheep

J Persson et al. Acta Vet Scand. 1974.

Abstract
in English, Swedish

PERSSON, J. and J. LUTHMAN: Some acute metabolic effects of parathyroid hormone in sheep. Acta vet. scand. 1974, 15, 381–397. — It is now well established that calcium ions play a key role in the activation of many different cell systems. Parathyroid hormone (PTH) causes a shift of calcium into bone cells, and lipolytic hormones have little or no effect in calcium-free media. In the present investigation sheep were used to study the acute effects of intravenous injection of bovine PTH on mineral and lipid metabolism. A significant initial hypocalcaemia was found in all groups of animals. The subsequent rise in plasma calcium was most pronounced in rams. Thyroid-ectomized animals showed a greater calcium response than did intacts. PTH was found to have a strong lipolytic effect, comparable to that of catecholamines, and a slight hyperglycaemic effect. The rise in plasma NEFA was blocked by nicotinic acid, while the hyper-glycaemia was potentiated. Hypophosphataemia was obtained in young rams but not in young ewes, and in elder ewes a slight increase in the plasma phosphate level was found. Plasma magnesium decreased in all groups after PTH injection, while PTH + nicotinic acid caused a rise in magnesium concentration. The results are discussed in the view of current knowledge of mineral and lipid metabolism.

parathyroid hormone; hypocalcaemia; lipolysis; sheep.

Akuta metaboliska effekter av parathormon hos får.

Under de senaste åren har det klarlagts att kalciumjoner är nödvändiga för aktivering av ett flertal olika cellsystem. Bl. a. gäller detta parathormonets effekt på skelettet och lipolytiska hormoners effekt på fettvävnaden. I den föreliggande undersökningen användes får för att studera de akuta effekterna på mineral- och fettmetabolismen efter intravenös injektion av parathormon (PTH). PTH medförde en signifikant initial hypokalcemi i samtliga grupper av djur. Den därpå följande hyperkalcemin var störst hos baggar, skillnaden i kalciumsvar mellan unga baggar och unga tackor var nästan signifikant. Hyperkalcemin var större hos thyreoidektomerade djur än hos intakta. Den lipolytiska effekten av PTH var kraftig, jämförbar med katekolamin-inducerad lipolys, medan glykosstegringen endast var ringa. Det lipolytiska svaret blockerades av nikotinsyra, medan hyperglykemin potentierades. Hypofosfatemi påvisades hos unga baggar, däremot inte hos unga tackor, och hos äldre tackor erhölls en liten stegring av halten oorganiskt fosfor. I samtliga grupper medförde PTH hypomagnesemi, medan PTH + nikotinsyra gav hypermagnesemi. De erhållna resultaten diskuteras med utgångspunkt från den aktuella kunskapen om mineral- och fettmetabolismen.

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