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. 1974 Oct;180(4):549-57.
doi: 10.1097/00000658-197410000-00019.

Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship?

E L Kaplan, G W Peskin, C Deveney, L Way, B Jaffe

Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship?

E L Kaplan et al. Ann Surg. 1974 Oct.

Abstract

In both normal volunteers and in patients with primary hyperparathyroidism, the induction of a metabolic alkalosis by infusion of sodium bicarbonate results in a decrease in serum calcium ion and in an increase of circulating parathyroid hormone concentrations. Bicarbonate infusion may serve in man as a new provocative test for release of parathyroid hormone. Furthermore, we speculate that the metabolic alkalosis which is found at times in patients with the Zollinger-Ellison syndrome and severe peptic ulcer disease may result in parathyroid gland stimulation.

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