doi: 10.1139/o79-157.
N-acylation of tyramines: purification and characterization of an arylamine N-acetyltransferase from rat brain and liver
- PMID: 44212
- DOI: 10.1139/o79-157
Item in Clipboard
N-acylation of tyramines: purification and characterization of an arylamine N-acetyltransferase from rat brain and liver
Can J Biochem.
1979 Oct.
Abstract
The N-acylation of tyramine isomers and other biogenic amines has been studied. The liver exhibits the highest activity towards tyramines, while the brain exhibits a low but significant activity. In the brain, tyramine N-acylation activity was heterogenously distributed. The arylamine N-acetyltransferase has been partially purified from both rat liver and brain, the two enzymes being quite similar with respect to their chromatographic properties, optimal pH requirement (pH 7.8), and their kinetic parameters. The product N-acetyltyramine is not oxidized by liver amidohydrolase or monoamine oxidase.
Similar articles
-
Purification and partial characterization of chicken liver acetyl coenzyme A: arylamine N-acetyltransferase.Comp Biochem Physiol B. 1987;86(3):601-6. doi: 10.1016/0305-0491(87)90455-x. Comp Biochem Physiol B. 1987. PMID: 3595092
-
Assay for acetyl-CoA:arylamine N-acetyltransferase by high-performance liquid chromatography applied to serotonin N-acetylation.Biochim Biophys Acta. 1990 Jan 19;1037(1):1-6. doi: 10.1016/0167-4838(90)90094-v. Biochim Biophys Acta. 1990. PMID: 2294966
-
Purification and biochemical characterization of hepatic arylamine N-acetyltransferase from rapid and slow acetylator mice: identity with arylhydroxamic acid N,O-acyltransferase and N-hydroxyarylamine O-acetyltransferase.Mol Pharmacol. 1989 May;35(5):599-609. Mol Pharmacol. 1989. PMID: 2725469
-
Sulfate conjugation of monoamines in human brain: purification and some properties of an arylamine sulfotransferase from cerebral cortex.J Neurochem. 1985 Sep;45(3):836-43. doi: 10.1111/j.1471-4159.1985.tb04070.x. J Neurochem. 1985. PMID: 3861769
-
[Molecular pharmacology of polymorphic arylamine N-acetyltransferase involved in the metabolism of arylamine drugs].Nihon Rinsho. 1992 Apr;50(4):877-86. Nihon Rinsho. 1992. PMID: 1619774 Review. Japanese.
Cited by
-
Evaluation of the diagnostic potential of urinary N-Acetyltyramine-O,β-glucuronide (NATOG) as diagnostic biomarker for Onchocerca volvulus infection.Parasit Vectors. 2016 May 23;9(1):302. doi: 10.1186/s13071-016-1582-6. Parasit Vectors. 2016. PMID: 27216752 Free PMC article.
-
Purification and properties of the enzyme arylamine N-acetyltransferase from the housefly Musca domestica.Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):149-54. doi: 10.1042/bj2950149. Biochem J. 1993. PMID: 8216209 Free PMC article.
-
Rats with Long-Term Cholestasis Have a Decreased Cytosolic but Maintained Mitochondrial Hepatic CoA Pool.Int J Mol Sci. 2023 Feb 22;24(5):4365. doi: 10.3390/ijms24054365. Int J Mol Sci. 2023. PMID: 36901795 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources