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Clinical Trial
. 1974 Nov 23;4(5942):442-4.
doi: 10.1136/bmj.4.5942.442.

Bromocriptine in Parkinsonism

D B Calne, P F Teychenne, L E Claveria, R Eastman, J K Greenacre, A Petrie
Clinical Trial

Bromocriptine in Parkinsonism

D B Calne et al. Br Med J. .

Abstract

Bromocriptine, a drug acting directly upon dopaminergic receptors, has been found to have a significant therapeutic action in a double-blind study of 20 patients with idiopathic Parkinsonism who were already receiving conventional therapy, including levodopa. Neurological deficits improved by almost 20% in severely disabled patients; amelioration of mildly affected patients was about 10%. Adverse reactions were similar to those encountered with levodopa-they were all dose-dependent and reversible. These observations are discussed in relation to certain theoretical advantages which might be expected from a drug which acts directly on dopaminergic receptors.

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References

    1. N Engl J Med. 1970 Jan 1;282(1):31-3 - PubMed
    1. Science. 1970 Dec 11;170(3963):1212-3 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9 - PubMed
    1. J Pharm Pharmacol. 1973 May;25(5):409-12 - PubMed

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