Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Oct 1;140(4):1057-67.
doi: 10.1084/jem.140.4.1057.

In vitro generation of memory lymphocytes reactive to transplantation antigens

N Hollander, H Ginsburg, M Feldman

In vitro generation of memory lymphocytes reactive to transplantation antigens

N Hollander et al. J Exp Med. .

Abstract

The in vitro generation of memory cells reactive to transplantation antigens is described. Blast cells, obtained from rat lymphocytes sensitized on xenogeneic or allogeneic fibroblast monolayers, reverted to secondary small lymphocytes after transfer from the foreign sensitizing to syngeneic monolayers. These secondary small lymphocytes had a limited in vitro life span of 4-6 wk. They manifested properties of memory cells: upon re-exposure to fibroblasts of the sensitizing phenotype, the secondary lymphocytes adhered to the fibroblast monolayer and transformed into blast cells with cytotoxic activity. The response of secondary lymphocytes was rapid, compared to that of normal lymphocytes, and directed specifically against the primary sensitizing antigens.

PubMed Disclaimer

References

    1. J Cell Physiol. 1963 Dec;62:273-86 - PubMed
    1. Proc R Soc Lond B Biol Sci. 1954 Dec 15;143(910):58-80 - PubMed
    1. Cell Immunol. 1972 Feb;3(2):213-30 - PubMed
    1. J Exp Med. 1955 Aug 1;102(2):157-77 - PubMed
    1. Immunology. 1971 Apr;20(4):457-68 - PubMed