Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Oct 1;140(4):1108-11.
doi: 10.1084/jem.140.4.1108.

Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement

S M Fu, H G Kunkel, H P Brusman, F H Allen Jr, M Fotino

Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement

S M Fu et al. J Exp Med. .

Abstract

HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.

PubMed Disclaimer

References

    1. Transplantation. 1971 Mar;11(3):268-73 - PubMed
    1. Science. 1972 Dec 15;178(4066):1201-3 - PubMed
    1. J Clin Invest. 1973 Jul;52(7):1601-7 - PubMed
    1. Adv Immunol. 1974;19(0):217-58 - PubMed