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. 1974 Oct;54(4):805-9.
doi: 10.1172/JCI107820.

Preferential binding of beta s globin chains associated with stroma in sickle cell disorders

A Bank, G Mears, R Weiss, J V O'Donnell, C Natta

Preferential binding of beta s globin chains associated with stroma in sickle cell disorders

A Bank et al. J Clin Invest. 1974 Oct.

Abstract

Sickle cell anemia (SS) is associated with abnormalities of the red cell membrane and decreased red cell deformability. The present study assesses globin chain binding to stroma in SS, sickle cell trait (AS), and nonsickling (AA) cells. The results indicate that there is preferential binding of newly synthesized beta(S) globin to red cell stroma in SS cells and preferential binding of beta(S) to stroma compared to beta(A) in AS cells. These studies show that beta(S) globin binding to stroma accompanies the membrane abnormalities in SS and AS patients.

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