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. 1974 Aug;55(4):320-7.

Morphological observations on the cellular and subcellular destination of intravenously administered liposomes

A W Segal, E J Wills, J E Richmond, G Slavin, C D Black, G Gregoriadis

Morphological observations on the cellular and subcellular destination of intravenously administered liposomes

A W Segal et al. Br J Exp Pathol. 1974 Aug.

Abstract

The cellular and subcellular fate of intravenously administered liposomes was traced by light and electron microscopy, using nitroblue tetrazolium (NBT) as a marker. Liposomes were found almost exclusively within phagocytic vacuoles of cells of the reticuloendothelial system. Fusion of lysosomes with phagocytic vacuoles and liposomal degradation were clearly visible. Liposomes may find wide application in the study and treatment of metabolic, infectious and neoplastic disease of phagocytic cells.

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References

    1. Biochemistry. 1968 Jun;7(6):2143-52 - PubMed
    1. J Clin Invest. 1969 Oct;48(10):1895-904 - PubMed
    1. Eur J Biochem. 1972 Jan 21;24(3):485-91 - PubMed
    1. Nature. 1973 Jul 20;244(5412):170-2 - PubMed
    1. Atherosclerosis. 1973 Nov-Dec;18(3):499-504 - PubMed

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