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. 1979;66(1):23-7.
doi: 10.1007/BF00431984.

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent

M Stanley, J Rotrosen, N Sculerati, S Gershon, C Kuhn, B M Cohen

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent

M Stanley et al. Psychopharmacology (Berl). 1979.

Abstract

The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

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