Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979;66(1):23-7.
doi: 10.1007/BF00431984.

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent

M Stanley, J Rotrosen, N Sculerati, S Gershon, C Kuhn, B M Cohen

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent

M Stanley et al. Psychopharmacology (Berl). 1979.

Abstract

The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

PubMed Disclaimer

References

    1. Psychopharmacology (Berl). 1977 Oct 20;54(2):183-6 - PubMed
    1. Science. 1976 Apr 30;192(4238):481-3 - PubMed
    1. Nature. 1977 Apr 14;266(5603):639-40 - PubMed
    1. Fed Proc. 1973 Feb;32(2):200-5 - PubMed
    1. Eur J Pharmacol. 1977 Aug 15;44(4):293-302 - PubMed

Publication types

LinkOut - more resources