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Comparative Study
. 1974 Jul;142(1):75-8.
doi: 10.1042/bj1420075.

A comparison of glucoside formation by liver preparations from the rabbit and the mouse

R S Labow, D S Layne
Comparative Study

A comparison of glucoside formation by liver preparations from the rabbit and the mouse

R S Labow et al. Biochem J. 1974 Jul.

Abstract

Liver homogenates from mice and from rabbits transfer glucose from UDP-[6-(3)H]glucose, at pH7.0, to oestradiol-17alpha, oestradiol-17beta, oestradiol-17alpha 3-glucuronide, p-nitrophenol and diethylstilboestrol. In the rabbit the phenolic steroids were better substrates than p-nitrophenol for the glucosyltransferase, whereas the reverse was true in the mouse. At pH8.0, rabbit liver, but not mouse liver, transferred glucose to oestradiol-17alpha 3-glucuronide in better yield than that at pH7.0. Evidence is presented for the presence of two glucosyltransferases in rabbit liver. One of these has a pH optimum at about 8.0, and is highly specific for oestradiol-17alpha 3-glucuronide, whereas the other, which has a pH optimum at about 7.0, is similar in this respect to the transferase in mouse liver.

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References

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