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. 1974 May;51(1):101-3.
doi: 10.1111/j.1476-5381.1974.tb09637.x.

Antagonism of the spinal action of diazepam by semicarbazide

N R Banna, S J Jabbur, N E Saadé

Antagonism of the spinal action of diazepam by semicarbazide

N R Banna et al. Br J Pharmacol. 1974 May.

Abstract

In spinal unanaesthetized cats, pretreatment with semicarbazide (200 mg/kg) 2-4.5 h prior to the administration of diazepam (1-4 mg/kg) completely blocked the enhancement of the segmental dorsal root reflex by the latter compound. Pyridoxine hydrochloride (200 mg/kg), given 3.5 h after semicarbazide, restored the spinal effect of diazepam administered 1 h later. The possibility of a link between diazepam and spinal gamma-aminobutyric acid is suggested and discussed.

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