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. 1974;2(6):342-50.
doi: 10.1185/03007997409114769.

Induction of labour and abortion by intravenous prostaglandins in pregnancies complicated by intra-uterine foetal death and hydatidiform mole

G Roberts

Induction of labour and abortion by intravenous prostaglandins in pregnancies complicated by intra-uterine foetal death and hydatidiform mole

G Roberts. Curr Med Res Opin. 1974.

Abstract

PIP: In a study of 32 patients, there were 29 cases of intra-uterine fetal death and 3 cases of hydatidiform mole. The intravenous administration of either prostaglandin E1, E2 or F2 successfully induced labor in 29 out of the 32 cases. 2 patients delivered following additional intravenous oxytocin and there was 1 failure due to the development of upper limb cyanosis. Side-effects included vomitng, phlebitis, facial flushing, rigors, pyrexia and uterine hypertonus. The method confirms the high success rates reported previously but the incidence of side-effects was disturbing. It is emphasized that prostaglandin E1 was used during this original research trial when prostaglandins were 1st investigated clinically. Prostaglandin E1 has not been made available commerically.

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