Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Dec;6(6):754-6.
doi: 10.1128/AAC.6.6.754.

Evaluation of bis-benzimidazoles in the treatment of murine lymphocytic choriomeningitis virus infections

J P Stella, J Michaelson, S L Dorfman, J H Morgan, C J Pfau

Evaluation of bis-benzimidazoles in the treatment of murine lymphocytic choriomeningitis virus infections

J P Stella et al. Antimicrob Agents Chemother. 1974 Dec.

Abstract

Seventy percent of the mice receiving (S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethandiol (A36683) in their drinking water lived at least four times longer than control mice when infected with 10 or 100 mean lethal doses of lymphocytic choriomeningitis virus strain UBC. In the next 4 months, most of the survivors died with lymphocytic choriomeningitis-like symptoms. Drug treatment during the first 7 days after infection was found to have no significant effect on virus titers in various organs. The sparing effect of the drug is discussed in terms of immunosuppression.

PubMed Disclaimer

References

    1. Appl Microbiol. 1970 Jul;20(1):123-8 - PubMed
    1. Appl Microbiol. 1972 Jan;23(1):117-22 - PubMed
    1. J Exp Med. 1972 Apr 1;135(4):860-73 - PubMed
    1. Antimicrob Agents Chemother. 1974 Dec;6(6):747-53 - PubMed
    1. J Exp Med. 1961 Apr 1;113:657-82 - PubMed

MeSH terms

LinkOut - more resources