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. 1974 Jul;51(3):459-61.
doi: 10.1111/j.1476-5381.1974.tb10684.x.

Tryptamine receptors in rat pulmonary artery

Y S Bakhle, T W Smith

Tryptamine receptors in rat pulmonary artery

Y S Bakhle et al. Br J Pharmacol. 1974 Jul.

Abstract

Tryptamine and 5-hydroxytryptamine (5-HT) are equipotent in contracting spiral strips of rat isolated pulmonary artery, in doses between 5 and 20 mug. These 5-HT receptors are blocked by low concentrations (c. 10(-9) M) of both methysergide and morphine. In rat isolated lung perfused via the pulmonary circulation, 5-HT caused increases in perfusion pressure which were also antagonized by methysergide and by morphine. These vascular 5-HT receptors cannot therefore be classified as M or D receptors and, furthermore, are different from those 5-HT receptors mediating release of spasmogens from rat isolated lungs.

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