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. 1974 Sep;52(1):104-6.
doi: 10.1111/j.1476-5381.1974.tb09694.x.

Stimulation of rat gastric adenylate cyclase by histamine and histamine analogues and blockade by burimamide

J H McNeil, S C Verma

Stimulation of rat gastric adenylate cyclase by histamine and histamine analogues and blockade by burimamide

J H McNeil et al. Br J Pharmacol. 1974 Sep.

Abstract

Histamine, 4-methylhistamine, 3-(beta-aminoethyl)-1,2,4 triazole and betazole, in that order, stimulated adenylate cyclase prepared from rat gastric tissue in a dose-dependent manner. Burimamide, an H(2)-receptor blocking agent, in concentrations of 1-5 x 10(-6) M antagonized this effect. The data lend some support to the hypothesis that elevated levels of cyclic adenosine 3',5'-monophosphate may be involved in histamine-stimulated gastric secretions and that H(2)-receptors are associated with adenylate cyclase.

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References

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