Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Sep;1(9):1183-99.
doi: 10.1093/nar/1.9.1183.

Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes

G C Noy, L Dalpra, A M Pedrini, G Ciarrocchi, E Giulotto, F Nuzzo, A Falaschi
Free PMC article

Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes

G C Noy et al. Nucleic Acids Res. 1974 Sep.
Free PMC article

Abstract

The stimulation of human lymphocytes with phytohaemoagglutinin induces the appearance or increase of several enzymes of DNA metabolism [Pedrini etal., Biochem. Biophys. Res. Comm., 47:1221(1972)]. With long times of stimulation, two phenomena are observed; an increase in the levels of DNA polymerase, of a DNase acting on single-stranded DNA, and of an endonuclease, occurring between the third and fourth day, in parallel with a wave of DNA synthesis;a second wave of increase of the same enzymes and of DNA ligase,occurring between the fifth and eight day when the DNA replication rate, as measured by thymidine-pulses, has decreased to values close to the background.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1965 Jul;54(1):158-65 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Nov;61(3):827-34 - PubMed
    1. J Biol Chem. 1969 Sep 25;244(18):5014-9 - PubMed
    1. Biochem J. 1964 Jan;90(1):147-9 - PubMed
    1. Exp Cell Res. 1969 Oct;57(2):257-62 - PubMed