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Comparative Study
. 1979 Dec;4(6):755-61.
doi: 10.1007/BF00964472.

Seizure proneness and neurotransmitter uptake

S C Bondy, J M Tepper, D B Bettis
Free article
Comparative Study

Seizure proneness and neurotransmitter uptake

S C Bondy et al. Neurochem Res. 1979 Dec.
Free article

Abstract

The ability of midbrain homogenates from two strains of mice to accumulate several putative neurotransmitters, or their precursor in the case of acetylcholine, has been examined. The high-affinity transport mechanisms toward glutamate, GABA, dopamine, and glycine were similar in both strains. The seizure-prone DBA21BG strain had a significantly higher capacity to transport choline than did the relatively seizure-resistant C57BL/6 IBC mice. Howaver, no difference in the density of muscarinic binding sites in the two mouse strains was found.

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