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. 1974 Aug;141(2):581-3.
doi: 10.1042/bj1410581.

Purification of rat liver S-adenosyl-L-methionine decarboxylase

A E Pegg

Purification of rat liver S-adenosyl-L-methionine decarboxylase

A E Pegg. Biochem J. 1974 Aug.

Abstract

The amount of S-adenosyl-l-methionine decarboxylase present in rat liver was enhanced 17-fold by administration of methylglyoxal bis(guanylhydrazone),* a specific inhibitor of the enzyme. The enzyme was purified 1400-fold in 50% yield from such liver extracts by chromatography on columns of the inhibitor bound to Sepharose. The purified enzyme had no spermidine synthetase activity.

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