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. 1979 May 15;35(5):576-8.
doi: 10.1007/BF01960327.

Altered or increased transfer-RNA methylation in the course of Interferon action on cells in culture?

H Koblet, R Wyler, U Kohler

Altered or increased transfer-RNA methylation in the course of Interferon action on cells in culture?

H Koblet et al. Experientia. .

Abstract

The induction of the antiviral state by Interferon might reflect the decrease of the rate of biosynthesis, the degradation or the alteration of one or several tRNAs. This could result in rate-limiting concentrations for codons common in viral RNA but rare in host mRNA. Altered methylation of tRNA could be the basis of such a phenomenon. However, we could not find an altered extent of methylation of total tRNA or an altered pattern of methylation, if mixed tRNAs were chromatographed on MAK- or BD-cellulose columns, despite a large range of conditions of pretreatment of chick embryo fibroblast cultures with interferon.

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References

    1. J Theor Biol. 1974 Jan;43(1):211-25 - PubMed
    1. Biochem Biophys Res Commun. 1976 Feb 23;68(4):1323-31 - PubMed
    1. FEBS Lett. 1974 Apr 15;41(1):125-30 - PubMed
    1. Virology. 1977 Jan;76(1):459-63 - PubMed
    1. Experientia. 1976 Dec 15;32(12):1514-7 - PubMed