Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 May 15;35(5):689-90.
doi: 10.1007/BF01960401.

Cell proliferation in the rat pituitary gland: a mechanism of control in prolactin cells

L E Kalbermann, I Szijan, J A Burdman

Cell proliferation in the rat pituitary gland: a mechanism of control in prolactin cells

L E Kalbermann et al. Experientia. .

Abstract

We investigated the relationship between prolactin content and DNA replication in the anterior pituitary gland. Thymidine incorporation in pregnant rats is significantly lower than in virgin controls. This is accompanied by a decreased activity of DNA polymerase. Sulpiride administration to pregnant rats enhances thymidine incorporation to levels similar to virgin controls. The results indicate a negative feedback between prolactin content and DNA synthesis in the rat anterior pituitary gland.

PubMed Disclaimer

References

    1. Nature. 1975 Jun 5;255(5508):497-8 - PubMed
    1. J Endocrinol. 1972 Apr;53(1):1-15 - PubMed
    1. J Neurochem. 1975 Apr;24(4):663-6 - PubMed
    1. Ann Intern Med. 1960 Mar;52:560-9 - PubMed
    1. Proc Soc Exp Biol Med. 1975 Feb;148(2):550-2 - PubMed