[Action of nonachlazine on thrombocyte aggregation induced by adrenaline]
- PMID: 446703
[Action of nonachlazine on thrombocyte aggregation induced by adrenaline]
Abstract
Nonachlazine at concentrations 10(-6)--10(-4)M inhibited platelet aggregation in rabbits induced by adrenalin in vitro. The same concentrations of the drug produced an appreciable increase in aggregation reversibility. Intravenous injection of nonachlazine into the rabbit 50 minutes prior to adrenalin protected the platelets against the aggregation activity of adrenalin but did not affect deaggregation.
Similar articles
-
[Experimental study of the effect of nonachlazine on the functional activity of the thrombocytes].Farmakol Toksikol. 1978 Sep-Oct;41(5):579-82. Farmakol Toksikol. 1978. PMID: 700082 Russian. No abstract available.
-
[Effect of etmozin on thrombocyte aggregation capacity].Biull Eksp Biol Med. 1982 May;93(5):74-6. Biull Eksp Biol Med. 1982. PMID: 6807371 Russian.
-
[Effect of nonachlazine on the adenylate cyclase system of the rabbit heart].Biull Eksp Biol Med. 1987 Nov;104(11):594-6. Biull Eksp Biol Med. 1987. PMID: 3676497 Russian.
-
[Pharmacological investigations on the adrenalin-thrombin-induced platelet aggregation in dogs].Folia Haematol Int Mag Klin Morphol Blutforsch. 1989;116(6):831-9. Folia Haematol Int Mag Klin Morphol Blutforsch. 1989. PMID: 2483700 German.
-
[Effect of nonachlazine on the temperature sensitivity of the lysosomal membranes of the heart muscle in rats in vitro].Farmakol Toksikol. 1985 May-Jun;48(3):41-5. Farmakol Toksikol. 1985. PMID: 4029378 Russian.