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. 1974 Nov 8;186(4163):536-8.
doi: 10.1126/science.186.4163.536.

Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor?

G M Grodsky, R Fanska, L West, M Manning

Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor?

G M Grodsky et al. Science. .

Abstract

The effects on insulin secretion of alpha and beta anomers of D-glucose were studied in the in vitro perfused rat pancreas. Both phases of insulin release showed consistent stereospecificity for alpha-glucose; this specificity indicates an action of glucose independent of intracellular glucose metabolism.

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