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. 1974 Sep;141(3):627-32.
doi: 10.1042/bj1410627.

Heterogeneity in tissue ferritins displayed by gel electrofocusing

J W Drysdale

Heterogeneity in tissue ferritins displayed by gel electrofocusing

J W Drysdale. Biochem J. 1974 Sep.

Abstract

1. Horse spleen ferritin and human liver ferritin were examined by gel electrofocusing under conditions that demonstrated equilibrium focusing. Both ferritins were resolved into multiple isoferritins. Both families of isoferritins were separable from one another. 2. Horse spleen ferritin was also resolved into five components by ion-exchange chromatography on DEAE-Sephadex A-50. Each of the major chromatographic fractions contained only a few of the isoferritins seen on gel electrofocusing. Each chromatographic fraction corresponded to different portions of the isoferritin profile. 3. These results indicate that the heterogeneity seen in many ferritins by gel electrofocusing represents structural heterogeneity in the ferritin population as isolated from the tissues.

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