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. 1979 Nov-Dec;74(6):611-20.
doi: 10.1007/BF01907503.

The role of ATP and lactic acid for mitochondrial function during myocardial ischemia

H Kahles, M M Gebhard, V A Mezger, H Nordbeck, C J Preusse, P G Spieckermann

The role of ATP and lactic acid for mitochondrial function during myocardial ischemia

H Kahles et al. Basic Res Cardiol. 1979 Nov-Dec.

Abstract

Phosphorylation rates of canine heart mitochondria isolated after various periods of myocardial ischemia after cardioplegic arrest were correlated with the myocardial ATP-, lactate- and undissociated lactic acid content as well as with interstitial H+-concentration. The following correlation coefficients were found: ATP: 0.87, lactate: 0.93, interstitial H+: 0.73. The calculated undissociated lactic acid content and the mitochondrial phosphorylation rate during ischemia showed a correlation coefficient of r = 0.95. Swelling measurements of mitochondria, isolated immediately after cardioplegic arrest, demonstrated that an undissociated lactic acid- and an ATP-concentration of 70 microM and 28 microM respectively are necessary for a half maximal swelling reaction under anaerobic conditions. The results suggest that the accumulation of undissociated lactic acid during myocardial ischemia could play an important role for mitochondrial damage in vivo.

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