Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Apr 12;12(4):349-55.
doi: 10.1007/BF01732029.

Energetics of peptide bond formation at elevated temperatures

A W Flegmann, R Tattersall

Energetics of peptide bond formation at elevated temperatures

A W Flegmann et al. J Mol Evol. .

Abstract

The free energies of formation of the peptide bond between carbobenzoxy-glycine and L-phenylalanine amide in aqueous solution at temperatures up to 60 degree C were calculated from experimentally determined equilibrium constants. The reaction was catalyzed by a thermophylic enzyme. The thermodynamic energy barrier to peptide bond formation was found to decrease with increasing temperature: the standard free energy of peptide bond formation did appear to become negative in the region of 60 degrees C. The possible significance of these results for peptide bond formation under prebiotic conditions is discussed.

PubMed Disclaimer

References

    1. J Mol Evol. 1977 Dec 29;10(3):211-20 - PubMed
    1. J Mol Evol. 1978 Dec 29;12(2):101-12 - PubMed
    1. Biochim Biophys Acta. 1966 Aug 24;124(2):339-50 - PubMed
    1. J Biol Chem. 1952 Mar;195(1):149-54 - PubMed
    1. Science. 1976 Jul 2;193(4247):68-70 - PubMed