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. 1972 Jan;69(1):139-42.
doi: 10.1073/pnas.69.1.139.

Evidence of gene diminution during the formation of the macronucleus in the protozoan, Stylonychia (DNA density-melting curves-micronuclear DNA-polytene chromosomes)

C J Bostock, D M Prescott

Evidence of gene diminution during the formation of the macronucleus in the protozoan, Stylonychia (DNA density-melting curves-micronuclear DNA-polytene chromosomes)

C J Bostock et al. Proc Natl Acad Sci U S A. 1972 Jan.

Abstract

The course of events by which a macronucleus is formed from a micronucleus after conjugation in the ciliated protozoan, Stylonychia, suggests that genetic diminution may occur. This idea is supported by determinations of the density profiles and melting curves for micro- and macronuclear DNAs. Macronuclear DNA consists of a single density component and melts as if it were a single component. Micronuclear DNA consists of four or more density components and melts as if it were a mixture of several DNAs of different base compositions. These data indicate that at least 60% of the micronuclear DNA components are absent from the macronuclear DNA.

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