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. 1972 Jan;69(1):93-7.
doi: 10.1073/pnas.69.1.93.

Genetic modification of electric properties in an excitable membrane (paramecium-calcium conductance-electrophysiological measurements-membrane mutant)

C Kung, R Eckert

Genetic modification of electric properties in an excitable membrane (paramecium-calcium conductance-electrophysiological measurements-membrane mutant)

C Kung et al. Proc Natl Acad Sci U S A. 1972 Jan.

Abstract

A behavioral deficiency produced by a single gene mutation in Paramecium aurelia was traced to impaired electric excitability of the cell membrane. Evidence is presented that the mutant membrane does not exhibit the normal depolarization-activated increase in calcium conductance responsible for regenerative depolarization in the wild type. Other electric properties characteristic of the wild-type membrane remain normal in the mutant.

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