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. 1972 Mar;69(3):726-9.
doi: 10.1073/pnas.69.3.726.

Electromechanochemical model of mitochondrial structure and function

D E Green, S Ji

Electromechanochemical model of mitochondrial structure and function

D E Green et al. Proc Natl Acad Sci U S A. 1972 Mar.

Abstract

A NEW MODEL OF MITOCHONDRIAL STRUCTURE AND FUNCTION IS PROPOSED ON THE BASIS OF FOUR FUNDAMENTAL ASSUMPTIONS: (a) electrons and protons are separated in the electron transfer complexes; (b) the ATPase undergoes conformational state-transitions induced by an electric field; (c) energy is transferred by an electric field effect; and (d) a conformationally strained protein system can be relaxed via a bond-forming chemical reaction. The model can explain all of the mitochondrial coupled processes and, in addition, it provides a reasonable rationalization of the correlation between mitochondrial structure and function.

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