Specificity of early protective responses induced by pseudomonas vaccines

Abstract

A single inoculation of pseudomonas vaccine protected mice against a 1 LD 100 challenge by nine different serotypes of Pseudomonas aeruginosa, 4 days after vaccination. Three inoculations of the same vaccine, given on consecutive days, protected mice for a longer time, against challenge by a wide range of Ps. aeruginosa serotypes, than the single inoculation of vaccine. The amount of vaccine inoculated only marginally influenced the non-specific response. F1 vaccines from eight serotypes of Ps. aeruginosa each induced protection against a different range of serotypes.