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. 1972 Jun;69(6):1421-4.
doi: 10.1073/pnas.69.6.1421.

Inhibition of influenza virus replication by -amanitin: mode of action

B W Mahy, N D Hastie, S J Armstrong

Inhibition of influenza virus replication by -amanitin: mode of action

B W Mahy et al. Proc Natl Acad Sci U S A. 1972 Jun.

Abstract

The replication of influenza virus in chick embryo fibroblast cells is inhibited by alpha-amanitin added during the first 2 hr of infection at concentrations similar to those required to inhibit cellular DNA-dependent RNA polymerase form II in vivo. Of two periods of increased RNA synthesis observed in cells infected with influenza virus, only the first, occurring from 0 to 2 hr after infection, is sensitive to alpha-amanitin. During this early period, there is a stimulation of the activity of DNA-dependent RNA polymerase II of nuclei isolated from infected cells. The data suggest that DNA transcription mediated by polymerase II is essential for influenza virus replication.

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References

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