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. 1972 Jun;69(6):1592-5.
doi: 10.1073/pnas.69.6.1592.

Juvenile hormone induction of esterases: a mechanism for the regulation of juvenile hormone titer

D Whitmore Jr, E Whitmore, L I Gilbert

Juvenile hormone induction of esterases: a mechanism for the regulation of juvenile hormone titer

D Whitmore Jr et al. Proc Natl Acad Sci U S A. 1972 Jun.

Abstract

Within a few hours after injection of juvenile hormone into Hyalophora gloveri pupae, several fast-migrating carboxylesterases (EC 3.1.1.1) that are sensitive to diisopropylfluorophosphate appear in the hemolymph. Treatment of the pupae with puromycin or actinomycin D prevents the appearance of these hemolymph enzymes, suggesting de novo synthesis of the carboxylesterases. Of the several other compounds investigated, only a potent mimic of the juvenile hormone is able to induce these enzymes. When the induced enzymes are incubated in vitro with (14)C-labeled juvenile hormone, the hormone is rapidly and efficiently degraded. It is suggested that these induced carboxylesterases play an important role in the regulation of juvenile hormone titer.

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