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. 1972 Jul;69(7):1883-6.
doi: 10.1073/pnas.69.7.1883.

Dopamine- -hydroxylase activity in mouse neuroblastoma tumors and in cell cultures

B Anagnoste, L S Freedman, M Goldstein, J Broome, K Fuxe

Dopamine- -hydroxylase activity in mouse neuroblastoma tumors and in cell cultures

B Anagnoste et al. Proc Natl Acad Sci U S A. 1972 Jul.

Abstract

Dopamine-beta-hydroxylase activity is present in mouse neuroblastoma C-1300 tumors. The activity is proportional to the weight of the tumor. Serum activity is markedly increased in mice that bear the tumors. Treatment of mice with 5-bromodeoxyuridine causes marked inhibition of tumor growth and decrease of dopamine-beta-hydroxylase activity in the serum. The histochemical studies reveal that 1-5% of the cells in mouse C-1300 neuroblastoma tumors contain catecholamines and that catecholamine-containing processes terminate mainly around blood vessels of the tumor. Dopamine-beta-hydroxylase is present in clonal neuroblastoma cell lines. The cell line with the greater tendency to form axon-like processes has a higher activity of this enzyme.

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