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. 1972 Aug;69(8):2115-9.
doi: 10.1073/pnas.69.8.2115.

Blocking by histones of accessibility to DNA in chromatin

A E Mirsky, B Silverman

Blocking by histones of accessibility to DNA in chromatin

A E Mirsky et al. Proc Natl Acad Sci U S A. 1972 Aug.

Abstract

The effect of histones on accessibility of DNA to DNase in chromatin of thymus nuclei has been studied by selective extraction of either lysine-rich or arginine-rich histones. It was found that all histones block accessibility but that, weight for weight, lysine-rich histones block much more effectively than do arginine-rich histones. We point to the contrast between accessibility of DNA to DNase and of DNA to RNA polymerase, and to what may be the similarity between accessibility to DNase and DNA polymerase.

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References

    1. Biochim Biophys Acta. 1965 Sep 6;108(1):67-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Oct;54(4):1204-12 - PubMed
    1. J Biol Chem. 1967 Mar 25;242(6):1220-6 - PubMed
    1. J Mol Biol. 1966 Dec 28;22(2):365-71 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Oct;61(2):592-7 - PubMed

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