doi: 10.1073/pnas.69.11.3119.
Mammalian cells with altered forms of RNA polymerase II
- PMID: 4508306
- PMCID: PMC389717
- DOI: 10.1073/pnas.69.11.3119
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Mammalian cells with altered forms of RNA polymerase II
Proc Natl Acad Sci U S A.
1972 Nov.
Abstract
Mutants of Chinese hamster ovary cells that are resistant to alpha-amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to alpha-amanitin. These results indicate that mutation to alpha-amanitin resistance involves a change of a structural gene.
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