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. 1972 Nov;69(11):3119-23.
doi: 10.1073/pnas.69.11.3119.

Mammalian cells with altered forms of RNA polymerase II

V L Chan, G F Whitmore, L Siminovitch

Mammalian cells with altered forms of RNA polymerase II

V L Chan et al. Proc Natl Acad Sci U S A. 1972 Nov.

Abstract

Mutants of Chinese hamster ovary cells that are resistant to alpha-amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to alpha-amanitin. These results indicate that mutation to alpha-amanitin resistance involves a change of a structural gene.

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References

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