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. 1972 Dec;69(12):3673-6.
doi: 10.1073/pnas.69.12.3673.

Partial duplication in the "hinge" region of IgA 1 myeloma proteins

B Frangione, C Wolfenstein-Todel

Partial duplication in the "hinge" region of IgA 1 myeloma proteins

B Frangione et al. Proc Natl Acad Sci U S A. 1972 Dec.

Abstract

The aminoacid sequence of the "hinge" region of two human IgA(1) myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA(2) myeloma protein, it is possible that IgA(1) molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.

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References

    1. Biochim Biophys Acta. 1963 May 14;71:468-71 - PubMed
    1. Biochemistry. 1972 Oct 10;11(21):3971-5 - PubMed
    1. Nature. 1969 Nov 8;224(5219):597-9 - PubMed
    1. J Mol Biol. 1968 May 14;33(3):893-906 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 May;63(1):78-85 - PubMed

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