Composition of gastric mucinous secretion from Heidenhain pouches of dogs treated with aspirin

Abstract

Principal glycoproteins and amino acids of secretions from Heidenhain pouches were studied in control and aspirin-treated dogs in the resting state of fasting and during stimulation with pentagastrin. All samples showed the presence of galactose, galactosamine, glucosamine, glucose, fucose, mannose, uronic acid and sulfate. Galactose and glucosamine were found in equimolar amounts, and the galactose/galactosamine ratio was 2/1. Pentagastrin induced the reduction in concentration of major carbohydrate components and amino acids of gastric mucus. The concentrations of major carbohydrate components and of amino acids of gastric secretions were lower in aspirin-treated animals than in controls.