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. 1979 Jun;24(3):501-14.

Effects of anti-inflammatory drugs on platelet aggregation in rabbits

S Takano, T Aikawa, T Oishi, M Goto, O Tamura, T Suzuki
  • PMID: 451335

Effects of anti-inflammatory drugs on platelet aggregation in rabbits

S Takano et al. Res Commun Chem Pathol Pharmacol. 1979 Jun.

Abstract

Effects of non-steroidal anti-inflammatory drugs (aspirin, indimethacin, flufenamic acid, tiaramide and HG-70) on rabbit platelet aggregation were studied using Evans aggoregometer and a modified form of Chandler's loop method. Tiaramide in 10(-4) and 10(-5)M inhibited effectively the aggregation caused by ADP in the optical density method and accelerated the restoration of the time course of disaggregation in the loop method. The other 4 drugs were ineffective. In collagen-induced aggregation all 5 drugs inhibited the aggregation. Among them tiaramide was most potent. Only tiaramide prolonged the time taken to induce snow storm and aggregates in the loop method.

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