Receptor mobility and receptor-cytoplasmic interactions in lymphocytes
- PMID: 4514314
- PMCID: PMC433515
- DOI: 10.1073/pnas.70.5.1442
Receptor mobility and receptor-cytoplasmic interactions in lymphocytes
Abstract
An analysis of the inhibition by concanavalin A of the mobility of lymphocyte surface receptors is used to construct an hypothesis on membrane receptor-cytoplasmic interactions. It is proposed that binding of multivalent lectins alters the interaction of an assembly of colchicine-binding proteins with lectin receptors and other receptors, and reciprocally that the state of the colchicine-binding assembly alters the mobility and distribution of surface receptors on the cell membrane. Observations of the effect of colchicine and related drugs on the inhibition of receptor mobility by concanavalin A lend support to this hypothesis. The proposed model has several implications for studies of the initial events of mitogenesis in lymphocytes as well as for cell-cell interactions in general.
Similar articles
-
Modulation of lymphocyte receptor mobility by locally bound concanavalin A.Proc Natl Acad Sci U S A. 1975 Apr;72(4):1579-83. doi: 10.1073/pnas.72.4.1579. Proc Natl Acad Sci U S A. 1975. PMID: 1055429 Free PMC article.
-
Modulation of lymphocyte receptor mobility by concanavalin A and colchicine.Ann N Y Acad Sci. 1975 Jun 30;253:455-69. doi: 10.1111/j.1749-6632.1975.tb19221.x. Ann N Y Acad Sci. 1975. PMID: 1096722 Review. No abstract available.
-
Feline lymphocytes: observations on surface membrane concanavalin A receptor mobility.Am J Vet Res. 1979 Jul;40(7):959-61. Am J Vet Res. 1979. PMID: 507498
-
Colchicine-sensitive structures and lymphocyte activation.J Immunol. 1976 Sep;117(3):1015-22. J Immunol. 1976. PMID: 956646
-
Molecular analysis of the initial events in mitogenesis.Soc Gen Physiol Ser. 1974;29:177-97. Soc Gen Physiol Ser. 1974. PMID: 4610762 Review. No abstract available.
Cited by
-
The problem of sea urchin egg fertilization and its implications for biological studies.Experientia. 1977 Oct 15;33(10):1263-7. doi: 10.1007/BF01920122. Experientia. 1977. PMID: 20321
-
Membrane difference in peripheral blood lymphocytes from patients with chronic lymphocytic leukemia and Hodgkin's disease.Proc Natl Acad Sci U S A. 1975 Jun;72(6):2428-32. doi: 10.1073/pnas.72.6.2428. Proc Natl Acad Sci U S A. 1975. PMID: 1056037 Free PMC article.
-
Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands.Proc Natl Acad Sci U S A. 1977 Nov;74(11):5031-5. doi: 10.1073/pnas.74.11.5031. Proc Natl Acad Sci U S A. 1977. PMID: 337308 Free PMC article.
-
Activation of early enzyme production in small lymphocytes in response to high, nonmitogenic concentrations of concanavalin A.Proc Natl Acad Sci U S A. 1980 Jun;77(6):3479-83. doi: 10.1073/pnas.77.6.3479. Proc Natl Acad Sci U S A. 1980. PMID: 6932033 Free PMC article.
-
Transmembrane linkage between surface glycoproteins and components of the cytoplasm in neutrophil leukocytes.J Cell Biol. 1981 Sep;90(3):743-54. doi: 10.1083/jcb.90.3.743. J Cell Biol. 1981. PMID: 7197281 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
