Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 May;70(5):1526-30.
doi: 10.1073/pnas.70.5.1526.

Biosynthesis of reticulocyte membrane proteins by membrane-free polyribosomes

H F Lodish

Biosynthesis of reticulocyte membrane proteins by membrane-free polyribosomes

H F Lodish. Proc Natl Acad Sci U S A. 1973 May.

Abstract

Intact rabbit reticulocyte cells synthesize two predominant species of membrane polypeptides; at least 10 reticulocyte membrane polypeptide species are not produced by the cells. Cell-free extracts of reticulocytes, free of any membranes or membrane-bound polyribosomes, synthesize large amounts of these two membrane polypeptides; one of these polypeptides appears to be modified, probably by loss of 20-40 amino acids, after it is incorporated into the membrane. Deprivation of hemin results in inhibition of synthesis by lysates of membrane proteins, globin, and all other cytoplasmic proteins.

PubMed Disclaimer

References

    1. J Cell Biol. 1966 Jul;30(1):73-96 - PubMed
    1. Biochemistry. 1971 Jun 22;10(13):2606-17 - PubMed
    1. Biochemistry. 1971 Jun 22;10(13):2617-24 - PubMed
    1. J Biol Chem. 1969 Oct 10;244(19):5118-24 - PubMed
    1. J Mol Biol. 1969 Jun 14;42(2):247-58 - PubMed

MeSH terms

LinkOut - more resources