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. 1973 Jul;70(7):2072-6.
doi: 10.1073/pnas.70.7.2072.

Action of rifamycin derivatives on RNA polymerase of human leukemic lymphocytes

M J Tsai, G F Saunders

Action of rifamycin derivatives on RNA polymerase of human leukemic lymphocytes

M J Tsai et al. Proc Natl Acad Sci U S A. 1973 Jul.

Abstract

The mechanism of inhibition of human RNA polymerase by four rifamycin derivatives was investigated. Derivative AF/013 (3-formyl rifamycin SV:O-n-octyloxime) with strong hydrophobic side chains prevents the polymerase from binding to DNA and also affects the size of RNA synthesized. Derivative PR/19 (3'-acetyl-1'-benzyl-2'-methylpyrrolo[3,2-c]-4-desoxy-rifamycin SV) only affects RNA synthesis when RNA polymerase has been previously incubated with the drug or when the reaction was performed at high salt concentration [0.14 M (NH(4))(2)-SO(4)]. Our results suggest that these drugs exert their inhibitory actions by binding to the enzyme instead of DNA.

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References

    1. J Antibiot (Tokyo). 1968 Mar;21(3):234-6 - PubMed
    1. Nature. 1969 Oct 18;224(5216):234-7 - PubMed
    1. Science. 1970 Oct 23;170(3956):447-9 - PubMed
    1. Annu Rev Biochem. 1971;40:711-40 - PubMed
    1. Bacteriol Rev. 1971 Sep;35(3):290-309 - PubMed

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