Thyroid hormone influence on the susceptibility of mice to audiogenic seizures
- PMID: 451624
- DOI: 10.1126/science.451624
Thyroid hormone influence on the susceptibility of mice to audiogenic seizures
Abstract
Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.
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