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Comparative Study
. 1979 Aug 10;205(4406):598-600.
doi: 10.1126/science.451624.

Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

Comparative Study

Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

T N Seyfried et al. Science. .

Abstract

Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.

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