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. 1973 Sep;70(9):2647-50.
doi: 10.1073/pnas.70.9.2647.

Synthesis of the myoglobin active site

C K Chang, T G Traylor

Synthesis of the myoglobin active site

C K Chang et al. Proc Natl Acad Sci U S A. 1973 Sep.

Abstract

A simple heme-imidazole compound, having the same geometry as the heme-imidazole complex in myoglobin, has been synthesized. This compound, ferropyrroporphyrin-N-[3-(1-imidazolyl)propyl]amide, reversibly binds oxygen in the solid state or when dissolved in a polystyrene film. These results suggest that the principal factors governing reversible oxygen binding are the electronic nature of the base (imidazole), neighboring-group effects of the basic group, and immobilization of the heme group.

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References

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