Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Jan;71(1):163-6.
doi: 10.1073/pnas.71.1.163.

Antibody-mediated suppression of lymphoma: participation of platelets, lymphocytes, and nonphagocytic macrophages

H S Shin, M L Hayden, C L Gately

Antibody-mediated suppression of lymphoma: participation of platelets, lymphocytes, and nonphagocytic macrophages

H S Shin et al. Proc Natl Acad Sci U S A. 1974 Jan.

Abstract

Humoral antibody directed against a grafted murine lymphoma can suppress the growth of the tumor in mice of the inbred strain native to the tumor. Antibody, however, cannot suppress the tumor growth in mice given 500 R of whole-body irradiation. When the tumor-antibody inoculum is admixed with lymphocytes or macrophages obtained from peritoneal exudate, macrophages experimentally rendered nonphagocytic, or with platelets isolated from peripheral blood, the tumor growth is suppressed in irradiated mice. These results indicate that mechanisms other than phagocytosis may play an important role in antibody-mediated suppression of tumor growth in vivo.

PubMed Disclaimer

References

    1. Nat New Biol. 1971 Jul 21;232(29):80-2 - PubMed
    1. Science. 1972 Jan 14;175(4018):194-6 - PubMed
    1. Proc Soc Exp Biol Med. 1972 Feb;139(2):684-9 - PubMed
    1. J Exp Med. 1972 Aug 1;136(2):375-80 - PubMed
    1. Immunology. 1973 Apr;24(4):655-69 - PubMed

LinkOut - more resources