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. 1974 Feb;72(1):31-39.
doi: 10.1017/s0022172400023172.

Biophysical and immunological studies on the differential effect of guanidine hydrochloride on type A and type B influenza viruses

T S David-West

Biophysical and immunological studies on the differential effect of guanidine hydrochloride on type A and type B influenza viruses

T S David-West. J Hyg (Lond). 1974 Feb.

Abstract

Guanidine hydrochloride selectively inactivated both the biological activity and the immunogenicity of the haemagglutinin of influenza A/X-7 (HON2). The residual neuraminidase was fully active biologically and immunologically. The reverse was observed with influenza B/ROB; with this virus the haemagglutinin was resistant, and was immunogenic; while the neuraminidase was selectively inactivated, and was not immunogenic.

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