Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Apr;71(4):1133-6.
doi: 10.1073/pnas.71.4.1133.

The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture

B C Halpern, B R Clark, D N Hardy, R M Halpern, R A Smith

The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture

B C Halpern et al. Proc Natl Acad Sci U S A. 1974 Apr.

Abstract

In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.

PubMed Disclaimer

References

    1. Biochem Med. 1970 Nov;4(3):215-39 - PubMed
    1. Cancer Res. 1973 Aug;33(8):1862-5 - PubMed
    1. Biochemistry. 1969 Sep;8(9):3496-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Sep;70(9):2585-9 - PubMed
    1. Proc Soc Exp Biol Med. 1956 Feb;91(2):305-7 - PubMed

MeSH terms

LinkOut - more resources