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. 1973 Aug;70(8):2253-5.
doi: 10.1073/pnas.70.8.2253.

Dopamine-beta-hydroxylase: a tetrameric glycoprotein

E F Wallace, M J Krantz, W Lovenberg

Dopamine-beta-hydroxylase: a tetrameric glycoprotein

E F Wallace et al. Proc Natl Acad Sci U S A. 1973 Aug.

Abstract

Dopamine-beta-hydroxylase (EC 1.14.2.1) has been isolated as a pure protein from bovine-adrenal glands. Although the molecular weight of the native protein is well established (290,000), sodium dodecyl sulfate-gel electrophoresis under dissociating conditions gave a single band with a molecular weight of about 75,000. The enzyme contains about 4% carbohydrate, which consists of residues of mannose, glucosamine, galactose, glucose, fucose, and sialic acid. The pure enzyme also contains about 4 atoms of copper per molecule. It is concluded that dopamine-beta-hydroxylase is a tetrameric glycoprotein.

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References

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