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Comparative Study
. 1974 May;71(5):1602-6.
doi: 10.1073/pnas.71.5.1602.

Blastic transformtion of mouse spleen lymphocytes by a water-soluble mitogen extracted from Nocardia

C Bona, C Damais, L Chedid
Comparative Study

Blastic transformtion of mouse spleen lymphocytes by a water-soluble mitogen extracted from Nocardia

C Bona et al. Proc Natl Acad Sci U S A. 1974 May.

Abstract

A water-soluble extract of Nocardia markedly increased in vitro [(3)H]thymidine incorporation by mouse spleen lymphocytes. The blastogenic activity of the extract and lipopolysaccharide was studied comparatively on various mouse lymphocyte subpopulations. The data obtained by [(3)H]thymidine incorporation and by electron microscopy have demonstrated that this preparation stimulates selectively mouse bone-marrow-derived cortisone-sensitive lymphocytes. This stimulation is related neither to a natural infection of mice with Nocardia organisms nor to the presence in Nocardia water-soluble mitogen of a lipopolysaccharide contaminant or of a lipopolysaccharide-like material.

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References

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