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. 1974 May;71(5):1808-10.
doi: 10.1073/pnas.71.5.1808.

Molecular heterosis for heat-sensitive enzyme alleles

R S Singh, J L Hubby, R C Lewontin

Molecular heterosis for heat-sensitive enzyme alleles

R S Singh et al. Proc Natl Acad Sci U S A. 1974 May.

Abstract

Heat denaturation studies were carried out and revealed hidden genic variants with the same net charge at the Octanol dehydrogenase-1 locus in Drosophila pseudoobscura. Studies of several genetic crosses between strains with different heat-sensitivity alleles showed that the F(1) retained more in vitro enzyme activity after being heat-treated for a specified amount of time at a given temperature than the heat-resistant parent. We call this phenomenon "heterosis for heat-stability of enzyme activity" and discuss its possible molecular mechanism, its relation to maintenance of genetic variation in natural populations, and its bearing on the "classical" and "balance" hypotheses.

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References

    1. Science. 1965 Aug 27;149(3687):936-43 - PubMed
    1. Genetics. 1969 Apr;61(4):841-58 - PubMed
    1. Nat New Biol. 1972 Sep 6;239(88):27-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3928-31 - PubMed

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